Table 6 Median nutritional biochemistry comparing CGMP-AA2 with Phe-free L-AA at baseline and week 26

Zinc μmol/L

14.4 (11.3–18.2)

p = 0.3

14.55 (12.3–17.5)

14.0 (10.5–16.4)

p = 0.24

C reactive protein mg/L

1.0 (1–11)

p = 0.27

1.0 (1–3)

1.0 (1–6)

p = 0.69

Whole blood Selenium

0.99^§ (0.48–1.38)

p = 0.57

0.98^* (0.75–1.23)

1.22^*§ (0.86–1.56)

^§ p = < 0.0001 ^* p = 0.0002

Selenium μmol/L

4-7y

0.91^§ (0.38–1.4)

p = 0.57

0.85^* (0.58–1.14)

1.12^*§ (0.58–1.35)

^§ p = 0.0005 ^* p = 0.0007

7-18y

Calcium mmol/L

2.49 (2.32–2.63)

p = 0.56

2.44 (2.31–2.59)

2.45 (2.25–2.68)

p = 0.77

Magnesium mmol/L

0.85 (0.72–1.0)

p = 0.68

0.82 (0.72–0.92)

0.84 (0.76–0.92)

p = 0.14

Phosphate mmol/L

1.38 (1.0–1.59)

p = 0.08

1.33 (1.0–1.58)

1.39 (1.0–1.71)

p = 0.20

25 hydroxy vitamin D nmol/L

95.3 (60–162)

p = 0.27

84.2 (47.6–139)

87.6 (47.9–158)

p = 0.49

Haemoglobin g/L

136 (101–156)

p = 0.55

141 (120–164)

135 (109–155)

p = 0.23

MCV fl

82 (75–91)

p = 0.48

84 (77–93)

82.5 (76–88)

p = 0.50

Ferritin μg/L

27.4^§§ (17.9–116.5)

p = 0.16

30.80 (17.6–75.6)

25.2^§§ (15.9–91.6)

^§§ p = 0.0006

Vitamin B12ng/L

1088 (333–1500)

p = 0.1

745 (308–1500)

922 (437–1500)

p = 0.23