Disease progression in women with X-linked adrenoleukodystrophy is slow

Table 7 Generalized Linear Mixed Model subgroup analysis 1 solely including women with two assessments (n=34)

	Fixed effect	B	SE	P value	95% Confidence Interval
	Fixed effect	B	SE	P value	Lower	Upper
EDSS	Baseline^	−0.215	0.051	< 0.0005*	− 0.317	− 0.112
	No neurological symptoms^^	−0.536	0.077	< 0.0005*	−0.690	−0.382
	Symptoms 10 years or shorter^^	−0.151	0.079	0.060	−0.309	0.006
ALDS	Baseline^	−0.016	0.044	0.708	−0.104	0.071
	No neurological symptoms^^	0.159	0.097	0.107	−0.035	0.353
	Symptoms 10 years or shorter^^	0.120	0.100	0.234	−0.080	0.321
	Age at examination	−0.004	0.004	0.345	−0.013	0.005
SF-36: PF	Baseline^	−0.000	0.027	0.994	−0.053	0.053
	No neurological symptoms^^	0.286	0.107	0.009*	0.073	0.499
	Symptoms 10 years or shorter^^	0.211	0.131	0.112	−0.051	0.472
SF-36: PCS	Baseline^	0.010	0.033	0.766	−0.056	0.076
	No neurological symptoms^^	0.234	0.111	0.039*	0.013	0.454
	Symptoms 10 years or shorter^^	0.201	0.135	0.142	−0.069	0.471

A higher EDSS score indicates higher disability. A lower ALDS score indicates higher disability. A lower physical functioning and physical component summary score indicates lower quality of life. ^ = Reference group is the follow-up visit; ^^ = Reference group is neurological symptoms > 10 years; * indicates a significant p value; ALDS = AMC Linear Disability Scale; B = coefficient; EDSS = Expanded Disability Status Scale; PCS = physical component summary; PF = physical functioning. SE = standard error; SF-36 = Short Form (36) Health Survey

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