Disease progression in women with X-linked adrenoleukodystrophy is slow

Table 4 Clinical validity – unrestricted, restricted and aided walking

	N	H	Unrestricted walking		Restricted walking		Walking with aid		P value
	N	H	N	Mean Rank	N	Mean rank	N	Mean rank	P value
EDSS	62	33.378	40	22.44	14	42.25	8	58	< 0.0005 *
ALDS	61	28.984	40	38.27	14	21.89	7	7.64	< 0.0005 *
SF-36: Physical functioning	61	20.216	40	37.98	14	21.82	7	9.50	< 0.0005 *
SF-36: Role physical	61	8.220	40	35.65	14	23.21	7	20.00	0.016 *
SF-36: Bodily pain	61	7.245	40	35.08	14	26.11	7	17.50	0.027 *
SF-36: General health perceptions	61	6.626	40	35.00	14	25.71	7	18.71	0.036 *
SF-36: Vitality	60	2.967	39	33.23	14	24.11	7	28.07	0.227
SF-36: Social functioning	61	1.960	40	32.79	14	30.00	7	22.79	0.375
SF-36: Role emotional	61	0.764	40	29.60	14	33.25	7	34.50	0.683
SF-36: Mental health	60	0.012	39	30.60	14	30.07	7	30.79	0.994
SF-36: Physical component summary	60	15.527	39	36.72	14	22.14	7	12.57	< 0.0005 *
SF-36: Mental component summary	60	2.278	39	28.90	14	30.36	7	39.71	0.320

Kruskal-Wallis tests were run to assess if there were differences in scores between the three ambulation groups at baseline. * indicates a significant p value. ALDS = AMC Linear Disability Scale; EDSS = Expanded Disability Status Scale; H = Kruskal-Wallis H statistic; N = number of patients; Role emotional = role limitations due to emotional problems; Role physical = role limitations due to physical problems; SF-36 = Short Form (36) Health Survey

ISSN: 1750-1172