Skip to main content

Advertisement

Table 3 Age-stratified adjusted incidence rate ratios for the three service types, MCAD deficiency cohort versus screen negative comparison cohort

From: Health services use among children diagnosed with medium-chain acyl-CoA dehydrogenase deficiency through newborn screening: a cohort study in Ontario, Canada

  Adjusted incidence rate ratio (95% CI)
< 1 year of age ≥1 year of age
Physician visits ED visits Hospitalizations Physician visits ED visits Hospitalizations
Cohort
 MCAD deficiency 1.39 (1.18–1.65) 2.41 (1.59–3.73) 2.87 (1.41–5.56) 1.51 (1.22–1.88) 1.98 (1.39–2.89) 12.97 (6.96–26.52)
 Screen negative Reference Reference Reference Reference Reference Reference
Sex
 Female 0.92 (0.91–0.92) 0.86 (0.85–0.86) 0.76 (0.75–0.77) 0.91 (0.91–0.92) 0.86 (0.85–0.87) 0.78 (0.77–0.80)
 Male Reference Reference Reference Reference Reference Reference
Season of birth
 Jan. – Apr. Reference Reference Reference Reference Reference Reference
 May – Aug. 1.01 (1.00–1.01) 1.04 (1.03–1.05) 0.98 (0.96–1.00) 0.96 (0.95–0.96) 0.95 (0.95–0.96) 0.94 (0.92–0.97)
 Sept. – Dec. 1.00 (0.99–1.00) 1.02 (1.00–1.03) 1.08 (1.06–1.11) 1.00 (0.99–1.00) 1.00 (0.99–1.01) 1.03 (1.00–1.05)
Birth weight
  < 2500 g 1.75 (1.74–1.77) 1.04 (1.02–1.06) 2.14 (2.08–2.21) 1.13 (1.12–1.14) 1.03 (1.01–1.05) 1.59 (1.51–1.66)
  ≥ 2500 g Reference Reference Reference Reference Reference Reference
Gestational age
  < 37 weeks 1.57 (1.56–1.58) 1.23 (1.21–1.26) 2.65 (2.57–2.73) 1.09 (1.09–1.10) 1.17 (1.15–1.19) 1.42 (1.36–1.48)
  ≥ 37 weeks Reference Reference Reference Reference Reference Reference
Socioeconomic status
  ‘Lower’ 1.00 (1.00–1.00) 1.23 (1.22–1.24) 1.09 (1.07–1.11) 0.96 (0.96–0.97) 1.12 (1.11–1.13) 1.10 (1.08–1.13)
  ‘Higher’ Reference Reference Reference Reference Reference Reference
Urban-rural status
 Rural 0.79 (0.78–0.79) 2.34 (2.30–2.37) 1.16 (1.13–1.20) 0.73 (0.72–0.73) 2.28 (2.25–2.31) 1.15 (1.11–1.20)
 Urban Reference Reference Reference Reference Reference Reference