Fig. 4

Functional aberrations in T and NK cells of NS patients. Increased cytokine production in stimulated T cells (i, p = 0.146, patient median 8.0, control median 4.1; and ii, p = 0.228, patient median 9.0, control median 3.4) and NK cells (vi, p = 0.199 patient median 13.6, control median 0.2), and decreased degranulation of NK cells (iii, p = 0.088, patient median 32.5, control median 38.0) despite high expression of granzyme B (iv, p = 0.903, patient median 81.0, control median 73.5 and v, p = 0.006, patient median without family III 82.9, control median 73.5) in stimulated NK cells of NS patients compared with healthy controls. Outliers in panels i and v are indicated with an asterisk and a circle, respectively