Table 6 Association between diagnostic delay and the prevalence of comorbidities in the CVID cohort. Results of proportional Cox regression (N = 972)
Comorbidities | HR: Mean (95% CI) | |||
|---|---|---|---|---|
Results adjusted for the age at CVID diagnosis | P value | Results adjusted for the age at symptoms onset | P value | |
Bronchiectasis | 1.01 (1.00; 1.03) | 0.0472 | 1.03 (1.01; 1.04) | 0.0001 |
Solid tumor | 1.01 (0.99; 1.04) | 0.2604 | 1.08 (1.04; 1.11) | < 0.0001 |
Lymphoma | 0.96 (0.91; 1.02) | 0.1919 | 0.98 (0.93; 1.04) | 0.5713 |
Splenomegaly | 1.00 (0.98; 1.02) | 0.9053 | 1.00 (0.98; 1.02) | 0.9611 |
Chronic lung disease (COPD, asthma) | 0.98 (0.96; 1.01) | 0.2543 | 0.99 (0.96; 1.02) | 0.4545 |
Autoimmunity (organ, systemic) | 1.00 (0.98; 1.03) | 0.9725 | 1.00 (0.98; 1.03) | 0.6958 |
Enteropathy | 1.02 (1.00; 1.04) | 0.1206 | 1.02 (1.00; 1.05) | 0.0447 |
Autoimmune cytopenia | 0.97 (0.92; 1.02) | 0.1973 | 0.96 (0.91; 1.01) | 0.0892 |
GLILD | 0.90 (0.80; 1.01) | 0.0771 | 0.91 (0.80; 1.02) | 0.1045 |
Granuloma (other than GLILD) | 0.98 (0.92; 1.03) | 0.3726 | 0.97 (0.92; 1.03) | 0.3362 |
Lymphoproliferation | 0.98 (0.93; 1.03) | 0.4132 | 0.99 (0.94; 1.04) | 0.6758 |