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Table 4 Proportion of Nutrient Intake from MF at Baseline and End of Study

From: One-year follow-up of B vitamin and Iron status in patients with phenylketonuria provided tetrahydrobiopterin (BH4)

Nutrients

< 18 years

≥18 years

Responders

Non-responders

Responders

Non-responders

Mean % (sd)

BL/End

P valuea (change)

Mean % (sd)

BL/End

P valuea (change)

Mean % (sd)

BL/End

P valuea (change)

Mean % (sd)

BL/End

P valuea (change)

Calories from MFb

21.3 (16.4)/ 4.7 (6.0)

0.008

36.1 (10.2)/ 27.0 (20.1)

0.25

19.5 (14.1)/ 4.0 (9.0)

0.06

23.5 (18.3)/ 30.1 (29.6)

0.81

Vitamin B6

38.63 (31.0)/ 12.3 (16.6))

0.02

69.6 (11.6)/ 55.7 (34.8)

0.46

25.4 (26.9)/9.4 (21.2)

0.43

44.7 (33.6)/ 50.7 (37.7)

0.63

Vitamin B12

47.1 (38.2)/ 22.2 (30.7)

0.02

87.4 (11.1)/ 69.6 (43.7)

0.64

47.1 (41.4)/ 13.1 (31.1)

0.13

62.3 (45.1)/ 61.9 (40.5)

1.0

Folate

46.7 (36.3)/ 15.9 (21.1)

0.02

76.5 (13.2)/ 62.1 (39.3)

0.38

40.2 (35.8)/11.1 (24.4)

0.13

49.5 (36.6)/ 56.8 (40.9)

1.0

Iron

43.2 (34.4)/ 13.1 (16.0)

0.02

74.1 (12.3)/ 59.3 (37.3)

0.38

42.1 (34.9)/ 11.8 (26.1)

0.13

46.6 (35.2)/ 57.8 (39.9)

1.0

  1. BL baseline, MF medical food, sd standard deviation, a p value for change over time obtained from signed rank test, α = 0.05
  2. b Combines primary and secondary MF in calculation of % intake from MF
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172