Fig. 1From: Cost-effectiveness analysis of lumacaftor and ivacaftor combination for the treatment of patients with cystic fibrosis in the United StatesMarkov model included five health states: mild (FEV1 > 70%), moderate (FEV1 40–70%), severe (FEV1 < 40%), post-transplant and death and two transition states: pulmonary exacerbation and lung transplant. Transitions to improved states were not allowed for the usual care arm. In some scenarios, transitions to improved states were allowed for the treatment armBack to article page