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Table 1 Conclusions of craniofacial findings in NF1 [17,18,19,20,21,22]

From: Craniofacial and oral alterations in patients with Neurofibromatosis 1

Dental age [22]
 No statistical difference compared to general population
Caries (DMFT; decayed, filled and missing teeth) [20]
 Lower DMFT index in patients with NF1 < 35 years
 Caries is not feature of NF1
Radiographical findings [16, 17, 21]
 Periapical cemental dysplasia (PCD)
 Bone deformities caused by plexiform neurofibromas
 Enlarged mandibular canal
 Retrognathic mandible and maxilla, and short cranial base
Oral soft tissue alterations [18]
 Found in 37% of patients with NF1
 Overgrowth of gingival soft tissue in 28% of patients with NF1
 Prominent lingual papillae in 40% of patients with NF1
 Mucosal tumors, most of which are neurofibromas
Speech characteristics [19]
 Voice quality alteration (eg. nasal voice, aberrant speech rhythm) in 35% of adults with NF1, and in 55% of children with NF1