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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials

Fig. 5

Inclusion criteria based on ASIS scores are plotted using three thresholds (ASIS 0.5 to 2; 0.75 to 2; 1 to 2) plotted in a1-a2 and a3 respectively. The ASIS bands plotted were extended to include 0.5–2.5, 0.75–2.5 and 1–2.5 (b1, b2 and b3 respectively). c The ASIS thresholds were plotted to demonstrate their influence on seizure/non-seizure cases (non-seizure cases in blue, seizure cases in red)

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