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Table 1 Initial signs and symptoms of disease

From: A prospective natural history study of Krabbe disease in a patient cohort with onset between 6 months and 3 years of life

Initial Signs and Symptoms All Ages n/N (%) Age of Onset
≤12 Months n/N (%) > 12 Months n/N (%)
Loss of developmental milestones 13/32 (41) 12/23 (52) 1/9 (11)
Irritability 12/32 (38) 8/23 (35) 4/9 (44)
Abnormal gait 7/32 (22) 1/23 (4) 6/9 (67)
Motor delay 5/32 (16) 5/23 (22) 0/9 (0)
Abnormal muscle tone 4/32 (13) 4/23 (17) 0/9 (0)
Slurred speech 3/32 (9) 1/23 (4) 2/9 (22)
Loss of vision 2/32 (6) 0/23 (0) 2/9 (22)
Abnormal arm movements 1/32 (3) 1/23 (4) 0/9 (0)
Macrocephaly 1/32 (3) 1/23 (4) 0/9 (0)
  1. Displays number and percentage of children who presented with each sign or symptom as an initial indicator of disease. Children are separated into age groups based on age at the onset of first symptoms