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Table 2 Comparison in average confidence interval width for the small sample adjusted methods on the log-odds and probability scales

From: Improving the analysis of composite endpoints in rare disease trials

Comparison Average reduction in C.I. width (%) Reduction in required sample size (%)
Log-odds
 Standard binary vs Augmented binary (GLS) 17.4 31.8
 Standard binary vs Augmented binary (GEE) 11.2 21.1
Difference in response probabilities
 Standard binary vs Augmented binary (GLS) 17.6 32.1
 Standard binary vs Augmented binary (GEE) 12.3 23.1
  1. C.I. confidence interval