Table 2 Comparison in average confidence interval width for the small sample adjusted methods on the log-odds and probability scales
From: Improving the analysis of composite endpoints in rare disease trials
Comparison | Average reduction in C.I. width (%) | Reduction in required sample size (%) |
|---|---|---|
Log-odds | ||
Standard binary vs Augmented binary (GLS) | 17.4 | 31.8 |
Standard binary vs Augmented binary (GEE) | 11.2 | 21.1 |
Difference in response probabilities | ||
Standard binary vs Augmented binary (GLS) | 17.6 | 32.1 |
Standard binary vs Augmented binary (GEE) | 12.3 | 23.1 |