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Table 3 Prevalence between Mexico and other countries

From: Amyloidosis due to TTR mutations in Mexico with 4 distincts genotypes in the index cases

Country

Total polulation (millions)

Surface area (thousands, km2

Number of diagnosed symptomatic TTR-FAP cases

Number of asymptomatic carriers of TTR gene mutation

Age range of patient cohort (years)

Portugal*

10.4

92.2

2000

> 500

18-87

Sweden*

9.6

438.6

250

Estimated 7500

25-85

France*

65.8

632.8

500

200

22-86

Itay*

60.8

302.1

500-600

250

25-85

Spain/ Majorca*

46.5

506

27

58

40-75

Bulgaria*

7.3

110

41

14

44-63

Germany*

80.5

357.3

120

60

28-69

Netherlands

16.8

41.5

45

23

25-75

Cyprus*

0.9

9.3

50

140

20-75

Turkey*

75

783.6

20-30

16

21-66

Japan**

127

378

110-135

37-78

Mexico

123.5

1964

85

26

18-77

  1. *Adapted from the European Network for TTR-FAP (Parman, Curr Opin Neurol 2016)
  2. **Data extracted from Kato-Motozaki Y J Neurol Sci 2008