From: Amyloidosis due to TTR mutations in Mexico with 4 distincts genotypes in the index cases
Country | Total polulation (millions) | Surface area (thousands, km2 | Number of diagnosed symptomatic TTR-FAP cases | Number of asymptomatic carriers of TTR gene mutation | Age range of patient cohort (years) |
---|---|---|---|---|---|
Portugal* | 10.4 | 92.2 | 2000 | > 500 | 18-87 |
Sweden* | 9.6 | 438.6 | 250 | Estimated 7500 | 25-85 |
France* | 65.8 | 632.8 | 500 | 200 | 22-86 |
Itay* | 60.8 | 302.1 | 500-600 | 250 | 25-85 |
Spain/ Majorca* | 46.5 | 506 | 27 | 58 | 40-75 |
Bulgaria* | 7.3 | 110 | 41 | 14 | 44-63 |
Germany* | 80.5 | 357.3 | 120 | 60 | 28-69 |
Netherlands | 16.8 | 41.5 | 45 | 23 | 25-75 |
Cyprus* | 0.9 | 9.3 | 50 | 140 | 20-75 |
Turkey* | 75 | 783.6 | 20-30 | 16 | 21-66 |
Japan** | 127 | 378 | 110-135 | 37-78 | |
Mexico | 123.5 | 1964 | 85 | 26 | 18-77 |