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Table 3 Prevalence between Mexico and other countries

From: Amyloidosis due to TTR mutations in Mexico with 4 distincts genotypes in the index cases

Country Total polulation (millions) Surface area (thousands, km2 Number of diagnosed symptomatic TTR-FAP cases Number of asymptomatic carriers of TTR gene mutation Age range of patient cohort (years)
Portugal* 10.4 92.2 2000 > 500 18-87
Sweden* 9.6 438.6 250 Estimated 7500 25-85
France* 65.8 632.8 500 200 22-86
Itay* 60.8 302.1 500-600 250 25-85
Spain/ Majorca* 46.5 506 27 58 40-75
Bulgaria* 7.3 110 41 14 44-63
Germany* 80.5 357.3 120 60 28-69
Netherlands 16.8 41.5 45 23 25-75
Cyprus* 0.9 9.3 50 140 20-75
Turkey* 75 783.6 20-30 16 21-66
Japan** 127 378 110-135 37-78
Mexico 123.5 1964 85 26 18-77
  1. *Adapted from the European Network for TTR-FAP (Parman, Curr Opin Neurol 2016)
  2. **Data extracted from Kato-Motozaki Y J Neurol Sci 2008