From: Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis
 | Maternal use of asthma medication |  | |||
---|---|---|---|---|---|
Ref. | First author, year | Exposure | ORcrude [95% CI] | ORadj [95% CI] | Adjustment/matching factors |
[73] | Garne, 2015 | Any anti-asthma medication | – | 1.6 [1.08, 2.51]b | Registry and maternal age |
– | 2.0 [1.30, 3.20]c | ||||
Beta-2-agonists in general | – | 1.5 [0.84, 2.66]b | Center, maternal age and use of inhaled corticosteroids | ||
– | 1.5 [0.79, 2.93]c | ||||
Inhaled beta-2-agonists | 1.7 [1.08, 2.80] | 1.5 [0.85, 2.68]b | Center, maternal age and use of corticosteroids | ||
2.3 [1.39, 3.75] | 1.8 [0.92, 3.44]c | ||||
– | 1.8 [1.11, 2.87]b | Center, maternal age | |||
– | 2.1 [1.26, 3.54]c | ||||
– | 1.5 [0.85, 2.69]b | Center, maternal age, systemic steroids and use of corticosteroids | |||
– | 1.5 [0.79, 2.94]c | ||||
– | 1.5 [0.83, 2.63]b | Center, maternal age, period (5-year intervals) and use of corticosteroids | |||
– | 1.8 [0.92, 3.45]c | ||||
– | 1.2 [0.35, 3.73]b,f | Center, maternal age, period (5-year intervals) and use of corticosteroids | |||
– | 0.8 [0.23, 2.76]c,f | ||||
Inhaled corticosteroids | 2.0 [1.10, 3.51] | 1.5 [0.74, 3.02]b | Center, maternal age and use of beta-2-agonists | ||
3.3 [1.81, 5.98] | 1.7 [0.73, 3.77]c | ||||
– | 2.0 [1.09, 3.48]b | Center, maternal age | |||
– | 2.8 [1.48, 5.17]c | ||||
– | 1.5 [0.74, 3.03]b | Center, maternal age, systemic steroids and use of beta-2-agonists | |||
– | 2.1 [0.94, 4.51]c | ||||
– | 1.5 [0.75, 3.07]b | Center, maternal age, period (5-year intervals) and use of beta-2-agonists | |||
– | 1.6 [0.72, 3.73]c | ||||
– | 1.2 [0.31, 4.68]b,f | Center, maternal age, period (5-year intervals) and use of beta-2-agonists | |||
– | 2.7 [0.78, 9.58]c,f | ||||
1.3 [0.41, 4.06]a,b,f | – | ||||
Combination treatments | – | 1.0 [0.31, 3.24]b | Center, maternal age and use of short-acting beta-2-agonists | ||
– | 1.4 [0.43, 4.28]c | ||||
Salbutamol | – | 1.6 [0.87, 2.88]b | Center, maternal age and use of inhaled corticosteroids | ||
– | 1.5 [0.78, 3.04]c | ||||
[53] | Zwink and Choinitzki, 2015 | Any anti-asthma medication | 0.8 [0.02, 29.50]d | – | – |
0.3 [0.01, 16.63]e | Â | Â | |||
[67] | Yau, 2013 | Pseudoephedrine | – | 1.3 [0.8, 2.3] | Matched and adjusted for further factors (not specified) |
[59] | Lin, 2012 | Anti-inflammatory use | – | 2.1 [1.09, 4.12] | Age, parity, race/ethnicity, education, alcohol use, smoking, gender, folic acid use, fever in first trimester |
Bronchodilator use | – | 0.9 [0.38, 2.01] | |||
[42] | Källén and Otterblad Olausson, 2007 | Any anti-asthma medication | – | 1.7 [1.11, 2.56] | Year of birth, maternal age, parity, smoking, and number of previous miscarriages |
Inhaled corticosteroids | – | 1.9 [1.00, 3.22] | |||
Salbutamol | – | 1.5 [0.50, 3.60g | |||
Terbutaline | – | 1.5 [0.82, 2.52]g | |||
Salmeterol | – | 2.5 [0.52, 7.37]g | |||
Budesonide | – | 1.9 [0.95, 3.42]g |