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Table 1 Evidence levels and strength of recommendations

From: Consensus clinical management guidelines for Niemann-Pick disease type C

Item Definition
Level of evidence
 A. High-quality evidence Further research is unlikely to change our confidence in the estimate of effect. Consistent evidence from the RCTs without important limitations or exceptionally strong evidence from observational studies.
 B. Moderate-quality evidence Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Evidence from RCTs with important limitations (inconsistent results, methodologic flaws, indirect or imprecise), or very strong evidence from observational studies.
 C. Low-quality evidence Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Evidence for at least one critical outcome from observational studies, case series, or from RCTs with serious flaws, or indirect evidence, or expert’s consensus.
Strength of recommendation
 1. Strong recommendation Recommendation can apply to most patients in most circumstances.
 2. Weak recommendation The best course of action may differ depending on circumstances or patient or society values. Other alternatives may be equally reasonable.
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