Variable | Change per month (Paired) | ||
---|---|---|---|
Before sirolimus | After sirolimus | P value | |
Pulmonary Function | (N = 18) | ||
FEV1 (mL) | −31.12 ± 30.78 | 16.11 ± 36.00 | 0.002 |
FEV1/pred (%) | −0.95 ± 0.82 | 0.30 ± 0.89 | < 0.001 |
FVC/pred (%) | −1.13 ± 0.93 | 0.71 ± 1.36 | 0.001 |
FEV1/FVC (%) | −0.82 ± 1.36 | 0.78 ± 2.16 | 0.019 |
RV/pred (%) | 2.50 ± 9.01 | 0.16 ± 8.30 | 0.497 |
TLC/pred (%) | 1.02 ± 4.49 | 1.15 ± 6.20 | 0.953 |
RV/TLC (%) | 0.78 ± 2.38 | 0.41 ± 2.58 | 0.688 |
DLCO/pred (%) | −0.72 ± 1.34 | 1.10 ± 2.28 | 0.043 |
Arterial Blood Gas | (N = 17) | ||
PaO2 (mmHg) | −0.55 ± 0.60 | 0.30 ± 1.19 | 0.018 |
PaCO2 (mmHg) | 0.005 ± 0.327 | 0.058 ± 0.194 | 0.170 |
P(A-a)O2 (mmHg) | 0.31 ± 0.92 | −0.75 ± 1.28 | 0.037 |