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Table 2 Evolution of the first eye affected and the second eye in five LHON patients during the cyclosporine trial

From: Cyclosporine A does not prevent second-eye involvement in Leber’s hereditary optic neuropathy

  First Eye Second Eye Inter eye comparaison at exit
  Mean values at baseline Mean values at exit P- value Mean values at baseline Mean values at exit P- value P- values
Visual acuity (logMar) 0,84 1,82 0,009* 0 1,50 0,001* 0,40
OCT Average RNFL thickness (μM) 142 97 0,057 112 122 0,57 0,30
Average GC-PL thickness (μM) 72,8 51,9 < 0,001* 80,4 56,8 < 0,001* 0,18
Visual visual field defect (dB) −5,2 −30,0 < 0,001* −1,4 −24,4 0,004* 0,25
  1. P-values calculated with Student’s t-test, *Significance of the bold datas