Congenital anomalies in neurofibromatosis 1: a retrospective register-based total population study

Table 3 Incidence and odds ratios of major congenital anomalies, stratified by NF1 status of mother and child

Mother / child	n ^a	Incidence, 1/1000	OR, unadjusted (95% CI)	OR, adjusted (95% CI)	P, unadjusted	P, adjusted
NF1 or non-NF1 / NF1^b	22	49.7	2.77 (1.70–4.51)	2.78 (1.71–4.54)	<.001	<.001
NF1 / NF1 ^b	7	56.5	3.44 (1.50–7.88)	3.27 (1.42–7.52)	.004	.005
NF1 / non-NF1 ^b	2	13.8	0.50 (0.12–2.04)	0.53 (0.13–2.21)	.332	.387
Non-NF1 / NF1 ^b	15	47.9	2.66 (1.49–4.74)	2.66 (1.48–4.78)	.002	.002
NF1 / NF1 or non-NF1^c	17	47.6	1.61 (0.93–2.77)	1.65 (0.94–2.89)	.089	.079

Adjusted ORs were adjusted for smoking during pregnancy, maternal age, year of pregnancy and parity (0/1+)
^aNumber of patients with major congenital anomaly
^bChildren born between 1987 and 2006
^cChildren born between 1987 and 2013

ISSN: 1750-1172