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Table 1 Summary GHS-R expression data and statistical findings

From: Receptor of ghrelin is expressed in cutaneous neurofibromas of individuals with neurofibromatosis 1

  Cutaneous Neurofibromas  
Large Small P-value
Mean (± standard deviation) Mean (± standard deviation)
Volume (mm3) 1923 (±2349) 63.9 (±62.1) <0.0001a
Total number of nuclei per neurofibroma 25,878 (±10,979) 5,2016 (±27,953)
Number of positive nuclei per neurofibroma 14,025 (±6310) 21,912 (±14,146)
Percent of positive nuclei per neurofibroma/n* 53.6% (±9.2)/48 41.1%(±13.1)/48 <0.0001b
Percent of positive nuclei (considering the tumors of the same individuals with volume difference ≥1000 mm3)/n* 52.9%(±8.6)/24 44.2%(±14.4)/24 0.01b
Percent of positive nuclei (considering the tumors of the same individuals with volume difference of ≥3000 mm3)/n* 53.6% (±8.0)/9 35.4% (±16.1)/9 0.015a
Percent of cells with strong staining / Number of tumors with predominance of cells with strong staining 24.1%d (±7.1)/42d 13.5% (±9)/20 <0.0001c
Percent of cells with moderate staining / Number of tumors with predominance of cells with moderate staining 17.9%d (±4.6)/13d 13.5% (±4.3)/8
Percent of cells with weak staining / Number of tumors with predominance of cells with weak staining 11.4% (±2.7)/0 (none) 14.1% (±4.2)/25
Area of analysis (mm2) 4.2 (±1.7) 10.2 (±6.3)
  1. * n, number of tumors
  2. aWilcoxon rank-sum test
  3. bPaired t-test
  4. cANOVA one-way (with Bonferroni correction)
  5. dvalues with statistical difference after Bonferroni correction