Fig. 4From: KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteersExposure-response analysis of KH176 plasma concentrations and a change from baseline for ECG derived TpTe intervals. The upper limit of normal (23.4 ms) is derived from the 95% confidence interval of the pre-dose values. In healthy subjects a dose of 100 mg BID resulted in maximum concentrations ranging from 303 to 458 ng/mLBack to article page