Fig. 1
From: Nuclear envelopathies: a complex LINC between nuclear envelope and pathology
The LINC complex, its interactors, and associated diseases. Schematic representation of the different nuclear envelope components and their interactions. The pathologies associated with mutations in the related genes are indicated in the corresponding boxes. LINC complex components (SUN proteins in green and Nesprins in light brown) are highlighted in the red box. EDMD: Emery-Dreifuss Muscular Dystrophy, RD: Restrictive Dermopathy, HGPS: Hutchinson-Gilford Progeria Syndrome, MADA: Mandibuloacral Dysplasia type A, MADB: Mandibuloacral Dysplasia type B, DCM: Dilated Cardiomyopathy, DCM-CD: Dilated Cardiomyopathy with Conduction Defects, NGPS: Nestor-Guillermo Progeria Syndrome, ADLD: Autosomal Dominant Leukodystrophy, LGMD: Limb-Girdle Muscular Dystrophy, CMT: Charcot-Marie-Tooth, FPLD: Familial Partial Lipodystrophy, WRN: Werner’s Syndrome