The complete European guidelines on phenylketonuria: diagnosis and treatment

Table 4 International reported protein recommendations for protein equivalent intake (g/kg/day) in PKU

Age y	Brussels Belgium [6]^,a	Munich Germany [6]^,a	Copenhagen Denmark [6]^,a	Madrid Spain [6]^,a	Milan Italy [6]^,a	Oslo Norway [6]^,a	Groningen Netherlands [6]^,a	Warsaw Poland [6]^,a	Ankara Turkey [6]^,a	Birmingham United Kingdom [6]^,b	Portugal [485]^,c	United Kingdom (Medical Research Counsil PKU) [486]	France [487]	USA [223]
0.1y	≤2	2–2.3	2–3	3	Depends on Phe tolerance	2.5	2–2.5	2.4	2	3	2–3	3	EAR age	2.5–3.5
1-3y	1.2	1.7	2	2.5		2–2.5	1.8–2	1.6	1.5	3	2–2.5	3	EAR age	≥30 g/d
4-10y	1.2	1.4–1.6	2	2		1.5–2	1.5	1.6	1.5	2	1–2	2	EAR age	≥40 g/d
>10y	1	0.8–1.1	10-14y: 1.5 >14y: 1	1.5		1–1.5	1–1.2	1.2	1.2	10-14y: 1.5 >14y: 1	1–1.5	unreported	EAR age	≥50 g/d to ≥65 g/d
Adult	No data collected	No data collected	No data collected	No data collected	No data collected	No data collected	No data collected	No data collected	No data collected	1	1	unreported	EAR age	≥70 g/d

EAR Estimated average requirement
^aAmount of protein equivalent from protein substitute (g/kg/day); ^b Total protein including protein from Phe exchanges (g/kg/day); ^c Protein substitute recommendation based on Phe-free L-amino acid supplements rather than protein equivalent

ISSN: 1750-1172