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Table 4 International reported protein recommendations for protein equivalent intake (g/kg/day) in PKU

From: The complete European guidelines on phenylketonuria: diagnosis and treatment

Age
y
Brussels Belgium [6],a Munich Germany [6],a Copenhagen Denmark [6],a Madrid Spain [6],a Milan Italy [6],a Oslo Norway [6],a Groningen Netherlands [6],a Warsaw Poland [6],a Ankara Turkey [6],a Birmingham United Kingdom [6],b Portugal [485],c United Kingdom (Medical Research Counsil PKU) [486] France [487] USA [223]
0.1y ≤2 2–2.3 2–3 3 Depends on Phe tolerance 2.5 2–2.5 2.4 2 3 2–3 3 EAR age 2.5–3.5
1-3y 1.2 1.7 2 2.5 2–2.5 1.8–2 1.6 1.5 3 2–2.5 3 EAR age ≥30 g/d
4-10y 1.2 1.4–1.6 2 2 1.5–2 1.5 1.6 1.5 2 1–2 2 EAR age ≥40 g/d
>10y 1 0.8–1.1 10-14y: 1.5
>14y: 1
1.5 1–1.5 1–1.2 1.2 1.2 10-14y: 1.5
>14y: 1
1–1.5 unreported EAR age ≥50 g/d to ≥65 g/d
Adult No data collected No data collected No data collected No data collected No data collected No data collected No data collected No data collected No data collected 1 1 unreported EAR age ≥70 g/d
  1. EAR Estimated average requirement
  2. aAmount of protein equivalent from protein substitute (g/kg/day); b Total protein including protein from Phe exchanges (g/kg/day); c Protein substitute recommendation based on Phe-free L-amino acid supplements rather than protein equivalent