Fig. 2From: Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I diseaseProcedures of ultrasound treatment in MPS I mice and B6 mice. Ultrasound was applied in the left side brain. Acoustic pressure 0.56Â MPa, PRF 1Â Hz, burst length 10Â ms, and ultrasound exposure time 60s were used in all ultrasound treatments. a MPS I mice treated with one-spot ultrasound. b MPS I mice treated with two-spot ultrasound. The total dose of MBs and laronidase used were the same as panel a. c B6 mice treated with one-spot ultrasound. d B6 mice treated with two-spot ultrasound. The total dose of MBs and EB used were the same as panel c Back to article page