Table 1 Clinical and demographic characteristics of 51 patients with familial Mediterranean fever before colchicine treatment
From: A survey of resistance to colchicine treatment for French patients with familial Mediterranean fever
All patients n = 51 | Group Ia n = 28 | Group IIb n = 23 | p values | |
|---|---|---|---|---|
Age at diagnosis (years) | 7.8 ± 8.7 | 12.2 ± 9.6 | 2.7 ± 2.8 | 0.001 |
Sex | 0.166 | |||
Male | 23 (45%) | 10 (36%) | 13 (57%) | |
Female | 28 (55%) | 18 (64%) | 10 (43%) | |
MEFV mutation | 0.235 | |||
M694V/M694V | 27 (51%) | 13 (43%) | 14 (61%) | |
M694V/M694I | 7 (13%) | 4 (13%) | 3 (13%) | |
M694I/M694I | 1 (2%) | 0 (0%) | 1 (4%) | |
M680I/M680I | 1 (2%) | 0 (0%) | 1 (4%) | |
M694V/V726A | 1 (2%) | 1 (3%) | 0 (0%) | |
M694V/I591T | 1 (2%) | 1 (3%) | 0 (0%) | |
M694V/E148Q | 1 (2%) | 1 (3%) | 0 (0%) | |
M726V/M680V | 1 (2%) | 1 (3%) | 0 (0%) | |
M694V/TRAPS polymorph. | 1 (2%) | 0 (0%) | 1 (4%) | |
E148Q/I692del/V726A | 1 (2%) | 0 (0%) | 1 (4%) | |
M694V/- | 4 (8%) | 1 (3%) | 3 (13%) | |
M694I/- | 1 (2%) | 1 (3%) | 0 (0%) | |
NA | 4 (7.5%) | 4 (13%) | 0 (0%) | |
Frequency of attacks | 0.019 | |||
> 1/2 weeks | 13 (26%) | 5 (18%) | 8 (35%) | |
> 1/month | 17 (33%) | 7 (25%) | 10 (44%) | |
> 1/3 months, <1/month | 3 (6%) | 1 (4%) | 2 (9%) | |
< 1/3 months, >3/year | 2 (4%) | 1 (4%) | 1 (4%) | |
< 3/year | 1 (2%) | 0 (0%) | 1 (4%) | |
NA | 15 (29%) | 14 (50%) | 1 (4%) | |
Duration of attacks (hr) | 57 ± 22.4 | 67 ± 17 | 50 ± 24 | 0.025 |
NA | 17 (33%) | 13 (46%) | 4 (17%) | |
Delay to treatment (years) | 8.7 ± 12.9 | 15 ± 15.9 | 2.4 ± 2.6 | <0.001 |
Total | 51 | 28 (55%) | 23 (45%) |