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Table 1 Clinical and demographic characteristics of 51 patients with familial Mediterranean fever before colchicine treatment

From: A survey of resistance to colchicine treatment for French patients with familial Mediterranean fever

  All patients
n = 51
Group Ia
n = 28
Group IIb
n = 23
p values
Age at diagnosis (years) 7.8 ± 8.7 12.2 ± 9.6 2.7 ± 2.8 0.001
Sex     0.166
 Male 23 (45%) 10 (36%) 13 (57%)  
 Female 28 (55%) 18 (64%) 10 (43%)  
MEFV mutation     0.235
M694V/M694V 27 (51%) 13 (43%) 14 (61%)  
M694V/M694I 7 (13%) 4 (13%) 3 (13%)  
M694I/M694I 1 (2%) 0 (0%) 1 (4%)  
M680I/M680I 1 (2%) 0 (0%) 1 (4%)  
M694V/V726A 1 (2%) 1 (3%) 0 (0%)  
M694V/I591T 1 (2%) 1 (3%) 0 (0%)  
M694V/E148Q 1 (2%) 1 (3%) 0 (0%)  
M726V/M680V 1 (2%) 1 (3%) 0 (0%)  
M694V/TRAPS polymorph. 1 (2%) 0 (0%) 1 (4%)  
E148Q/I692del/V726A 1 (2%) 0 (0%) 1 (4%)  
M694V/- 4 (8%) 1 (3%) 3 (13%)  
M694I/- 1 (2%) 1 (3%) 0 (0%)  
 NA 4 (7.5%) 4 (13%) 0 (0%)  
Frequency of attacks     0.019
  > 1/2 weeks 13 (26%) 5 (18%) 8 (35%)  
  > 1/month 17 (33%) 7 (25%) 10 (44%)  
  > 1/3 months, <1/month 3 (6%) 1 (4%) 2 (9%)  
  < 1/3 months, >3/year 2 (4%) 1 (4%) 1 (4%)  
  < 3/year 1 (2%) 0 (0%) 1 (4%)  
 NA 15 (29%) 14 (50%) 1 (4%)  
Duration of attacks (hr) 57 ± 22.4 67 ± 17 50 ± 24 0.025
 NA 17 (33%) 13 (46%) 4 (17%)  
Delay to treatment (years) 8.7 ± 12.9 15 ± 15.9 2.4 ± 2.6 <0.001
Total 51 28 (55%) 23 (45%)  
  1. Data are n (%) or mean ± SD
  2. aGroup I: Adult care setting
  3. bGroup II: Pediatric care setting