Evolution of structural neuroimaging biomarkers in a series of adult patients with Niemann-Pick type C under treatment

Table 3 Changes in FA in NPC patients compared to controls

ROI		NPC (m ± SD [min-max])	Controls (m ± SD [min-max])	p
Global mean		0.436 ± 0.023 [0.391–0.468]	0.469 ± 0.023 [0.423_0.502]	0.028
Anterior corona radiata	L	0.365 ± 0.048 [0.299–0.446]	0.405 ± 0.030 [0.365–0.444]	0.083
Anterior corona radiata	R	0.358 ± 0.035 [0.316–0.421]	0.409 ± 0.031 [0.438–0.531]	0.015
Anterior limb of internal capsule	L	0.449 ± 0.029 [0.409–0.507]	0.484 ± 0.029 [0.456–0.543]	0.028
Anterior limb of internal capsule	R	0.450 ± 0.025 [0.415–0.496]	0.500 ± 0.029 [0.456–0.543]	0.007
Cingulate gyrus	L	0.386 ± 0.027 [0.342–0.424]	0.431 ± 0.031 [0.392–0.467]	0.002
Cingulate gyrus	R	0.359 ± 0.025 [0.321–0.389]	0.409 ± 0.024 [0.373–0.444]	0.015
Body corpus callosum		0.473 ± 0.044 [0.408–0.533]	0.531 ± 0.054 [0.448–0.608]	0.032

ROI analysis found significantly decreased FA in NPC patients in the corpus callosum, the corona radiata, the internal capsule and the cingulate gyrus in particular. m : mean; SD : standard deviation; min : minimum; max : maximum, L : left; R: right

ISSN: 1750-1172