Table 4 Health-Related Quality of Life by Time since Diagnosis and Cardiac Involvement
From: The burden of amyloid light chain amyloidosis on health-related quality of life
Time since diagnosis | Cardiac involvement | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
<12 months n = 52 | ≥12 months n = 289 | No n = 163 | Yes n = 178 | |||||||
Mean (SD) | Mean (SD) | P value | Mean (SD) | Mean (SD) | P value | |||||
SF-36v2 norm-based scalesa | ||||||||||
Physical functioning (PF) | 38.7 (12.4) | 43.2 (10.2) | 0.015 | 44.5 (10.9) | 40.7 (10.0) | <0.001 | ||||
Role physical (RP) | 35.6 (12.7) | 41.4 (10.9) | 0.001 | 41.8 (11.7) | 39.3 (10.9) | 0.043 | ||||
Bodily pain (BP) | 44.0 (11.6) | 47.0 (10.4) | 0.099 | 47.2 (10.8) | 46.1 (10.4) | 0.257 | ||||
General health (GH) | 38.8 (11.7) | 39.4 (10.3) | 0.827 | 40.9 (10.5) | 37.7 (10.4) | 0.005 | ||||
Vitality (VT) | 40.9 (12.1) | 45.1 (10.8) | 0.027 | 44.9 (11.5) | 44.1 (10.7) | 0.530 | ||||
Social functioning (SF) | 38.7 (13.3) | 44.5 (10.9) | 0.003 | 43.8 (11.7) | 43.5 (11.3) | 0.786 | ||||
Role emotional (RE) | 41.0 (15.1) | 46.1 (11.5) | 0.038 | 45.3 (12.0) | 45.3 (12.5) | 0.900 | ||||
Mental health (MH) | 44.8 (13.0) | 49.8 (10.0) | 0.012 | 48.9 (10.8) | 49.2 (10.5) | 0.803 | ||||
SF-36v2 Summary Scores | ||||||||||
P Physical Component Summary (PCS) | 38.2 (11.9) | 41.2 (9.9) | 0.064 | 42.7 (10.6) | 38.9 (9.6) | <0.001 | ||||
Mental Component Summary (MCS) | 43.5 (13.5) | 48.7 (11.1) | 0.012 | 47.2 (11.9) | 48.5 (11.4) | 0.348 | ||||
Global assessment of functioning | 59.1 (31.2) | 72.2 (21.6) | 0.015 | 73.1 (23.5) | 67.5 (23.7) | 0.013 | ||||
Patient Global Impression–Severity Scale (PGI-S) | n | % | n | % | n | % | n | % | ||
<0.001 | <0.001 | |||||||||
Not severe at all | 11 | 21.2 | 122 | 42.2 | 84 | 51.5 | 49 | 27.5 | ||
Mild | 12 | 23.1 | 80 | 27.7 | 40 | 24.5 | 52 | 29.2 | ||
Moderate | 15 | 28.8 | 66 | 22.8 | 26 | 16.0 | 55 | 30.9 | ||
Severe | 9 | 17.3 | 14 | 4.8 | 8 | 4.9 | 15 | 8.4 | ||
Very severe | 5 | 9.6 | 7 | 2.4 | 5 | 3.1 | 7 | 3.9 | ||