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Table 4 Health-Related Quality of Life by Time since Diagnosis and Cardiac Involvement

From: The burden of amyloid light chain amyloidosis on health-related quality of life

  Time since diagnosis   Cardiac involvement  
  <12 months n = 52 ≥12 months n = 289   No n = 163 Yes n = 178  
  Mean (SD) Mean (SD) P value Mean (SD) Mean (SD) P value
SF-36v2 norm-based scalesa
 Physical functioning (PF) 38.7 (12.4) 43.2 (10.2) 0.015 44.5 (10.9) 40.7 (10.0) <0.001
 Role physical (RP) 35.6 (12.7) 41.4 (10.9) 0.001 41.8 (11.7) 39.3 (10.9) 0.043
 Bodily pain (BP) 44.0 (11.6) 47.0 (10.4) 0.099 47.2 (10.8) 46.1 (10.4) 0.257
 General health (GH) 38.8 (11.7) 39.4 (10.3) 0.827 40.9 (10.5) 37.7 (10.4) 0.005
 Vitality (VT) 40.9 (12.1) 45.1 (10.8) 0.027 44.9 (11.5) 44.1 (10.7) 0.530
 Social functioning (SF) 38.7 (13.3) 44.5 (10.9) 0.003 43.8 (11.7) 43.5 (11.3) 0.786
 Role emotional (RE) 41.0 (15.1) 46.1 (11.5) 0.038 45.3 (12.0) 45.3 (12.5) 0.900
 Mental health (MH) 44.8 (13.0) 49.8 (10.0) 0.012 48.9 (10.8) 49.2 (10.5) 0.803
SF-36v2 Summary Scores
 P Physical Component Summary (PCS) 38.2 (11.9) 41.2 (9.9) 0.064 42.7 (10.6) 38.9 (9.6) <0.001
 Mental Component Summary (MCS) 43.5 (13.5) 48.7 (11.1) 0.012 47.2 (11.9) 48.5 (11.4) 0.348
Global assessment of functioning 59.1 (31.2) 72.2 (21.6) 0.015 73.1 (23.5) 67.5 (23.7) 0.013
Patient Global Impression–Severity Scale (PGI-S) n % n %   n % n %  
     <0.001      <0.001
 Not severe at all 11 21.2 122 42.2   84 51.5 49 27.5  
 Mild 12 23.1 80 27.7   40 24.5 52 29.2  
 Moderate 15 28.8 66 22.8   26 16.0 55 30.9  
 Severe 9 17.3 14 4.8   8 4.9 15 8.4  
 Very severe 5 9.6 7 2.4   5 3.1 7 3.9  
  1. aSF-36v2, SF-36v2 Health Survey