Table 2 Disease and Treatment Characteristics by Time since Diagnosis and Cardiac Involvement
From: The burden of amyloid light chain amyloidosis on health-related quality of life
Time since diagnosis | Cardiac involvement | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
<12 months n = 52 | ≥12 months n = 289 | No n = 163 | Yes n = 178 | |||||||
n | % | n | % | P value | n | % | n | % | P value | |
No. organs involved | 0.047 | <0.001 | ||||||||
One | 20 | 38.5 | 75 | 26.0 | 71 | 43.6 | 24 | 13.5 | ||
Two | 16 | 30.8 | 73 | 25.3 | 42 | 25.8 | 47 | 26.4 | ||
Three or more | 16 | 30.8 | 141 | 48.8 | 50 | 30.7 | 107 | 60.1 | ||
No. treatment series received | 0.889 | |||||||||
None | 8 | 15.4 | 12 | 4.2 | <0.001 | 12 | 7.4 | 8 | 4.5 | |
One | 16 | 30.8 | 54 | 18.7 | 32 | 19.6 | 38 | 21.3 | ||
Two | 5 | 9.6 | 71 | 24.6 | 34 | 20.9 | 42 | 23.6 | ||
Three | 4 | 7.7 | 57 | 19.7 | 29 | 17.8 | 32 | 18.0 | ||
Four | 5 | 9.6 | 20 | 6.9 | 12 | 7.4 | 13 | 7.3 | ||
Five or more | 14 | 26.9 | 75 | 26.0 | 44 | 27.0 | 45 | 25.3 | ||
Ever underwent stem cell transplantation (% yes) | 5 | 9.8 | 175 | 60.6 | <0.001 | 89 | 54.6 | 91 | 51.4 | 0.556 |
Most recent hematologic response statusa | <0.008 | 0.135 | ||||||||
No response to treatment | 5 | 11.6 | 15 | 5.4 | 9 | 6.0 | 11 | 6.5 | ||
Partial hematologic response or partial remission | 19 | 44.2 | 107 | 38.5 | 62 | 41.1 | 64 | 37.7 | ||
Complete hematologic response or complete remission | 10 | 23.3 | 130 | 46.8 | 58 | 38.4 | 82 | 48.2 | ||
I do not know | 9 | 20.9 | 26 | 9.4 | 22 | 14.6 | 13 | 7.7 | ||