Fig. 3
From: Multi-criteria decision analysis (MCDA): testing a proposed MCDA framework for orphan drugs
Scenario testing of the criteria with different weighting applied in each scenario. Note: Criteria excluded in Scenario 2: Level of research undertaken; Level of effectiveness uncertainty; Manufacturing complexity; Unique indication or not. Criteria excluded in Scenario 3: Manufacturing complexity; Unique indication or not. PAH: Pulmonary arterial hypertension; MPS II: Mucopolysaccharidosis II; LGS: Lennox-Gastaut syndrome; MPS VI: Mucopolysaccharidosis VI; PNH: Paroxysmal nocturnal haemoglinuria; MDS: Myelodysplastic syndromes
