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Table 2 Baseline manifestations of TSC reported in TOSCA

From: TuberOus SClerosis registry to increase disease Awareness (TOSCA) – baseline data on 2093 patients

Manifestations of TSC Patients at baseline, n (%)
Neurological
 SEGA 510 (24.4)
 Cortical tuber 1721 (82.2)
 SEN 1636 (78.2)
 Cerebral white matter radial migration lines 429 (20.5)
Renal
 Renal angiomyolipoma 987 (47.2)
 Multiple renal cysts 477 (22.8)
 Polycystic kidneys 73 (3.5)
 Impaired renal function 43 (2.1)
 Renal malignancy 24 (1.1)
Pulmonary
 Lymphangioleiomyomatosis 144 (6.9)
Cardiavascular
 Cardiac rhabdomyoma 717 (34.3)
Dermatologic
  ≥ 3 hypomelanotic macules 1399 (66.8)
 Facial angiofibroma 1199 (57.3)
 Shagreen patch 573 (27.4)
 Ungual or periungual fibromas 350 (16.7)
 Forehead plaque 295 (14.1)
 Confetti lesions 179 (8.6)
Ophthalmologic
 Retinal hamartoma 294 (14.0)
Epilepsy 1748 (83.5)
  1. SEGA subependymal giant cell astrocytoma, SEN subependymal nodule, TOSCA TuberOus SClerosis registry to increase disease Awareness