Fig. 3
From: Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?
Immunofluorescent detection of the Notch1 intracellular domain (NICD) in the glomerular cells of SIOD patient and unaffected control kidneys. Immunostaining with anti-NICD (Alexa Fluor 594) in positive control skin (a), unaffected control kidney (b), and SIOD patient kidneys (c-j). The nuclei were counterstained with 4', 6-diamidino-2-phenylindole (DAPI). The boxed regions on the left correspond to the higher magnification images on the right. Scale bars: overview images (400×) = 100 microns; higher magnification images (1000×) = 10 microns. Abbreviations: DAPI, 4', 6-diamidino-2-phenylindole; NICD, Notch1 intracellular domain