Fig. 4

Biochemical parameters of lipid profile, homocysteine and blood pressure in patients with phenylketonuria classified according to their body mass index. Box-plot diagrams showing A) Triglycerides (mg/dL), B) Total Cholesterol (mg/dL), C) HDL-Cholesterol (mg/dL), D) Homocysteine (μmol/L), E) Systolic BP (mmHg) and F) Diastolic BP (mmHg). The X-axis indicates the underweight, normal and overweight & obese groups in our patients with phenylketonuria. Box-plots show median values (solid horizontal line); 25th and 75th percentiles (box); minimum and maximum values (bars); outliers (open circles). The * indicates the statistical significant differences: * p < 0.05, ** p < 0.01 and *** p < 0.001, using the statistical tests described in the Methods Section. BMI: body max index; HDL-cholesterol: high-density lipoprotein cholesterol; BP: blood pressure