Fig. 2From: The role of small in-frame insertions/deletions in inherited eye disorders and how structural modelling can help estimate their pathogenicityIntegrative protein structure modeling for two variants identified in individuals with retinal dystrophy. Affected amino acids are highlighted in red. a Model of the RP2 c.260_268del, p. (Thr87_Cys89del) variant. The main chain backbone atoms (white/grey lines) and the hydrogen bond network (brown lines) of the affected protein region are shown. The variant is found in an extended set of β-sheets that form a complex set of hydrogen bonds. b Homology model of the FSCN2 c.1071_1073del, p. (Lys357del) variant. The main chain backbone atoms (white/grey lines) of a small part of the protein is shown. The deletion affects a residue in a surface loop, away from known functional or interaction sitesBack to article page