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Table 1 Treatment Profiles for all Patients

From: Alternative laronidase dose regimen for patients with mucopolysaccharidosis I: a multinational, retrospective, chart review case series

    Laronidase Regimen
    0.58 mg/kg Weekly 1.2 mg/kg Every other week
Patient ID MPS I Phenotype Age at Dx Age at Start Duration Age at Start Duration
   years
1 H 2.42 4.25 1.66 6.00 7.75
2 H 1.17 1.83 4.33 6.17 6.33
3 H 1.67 2.08 1.83 3.92 1.00
  Mean (SD) 1.75 (0.63) 2.72 (1.33) 2.61 (1.49) 5.36 (1.25) 5.03 (3.56)
  Median
(Range)
1.67 2.08 1.83 6.00 6.33
  (1.17-2.42) (1.83-4.25) (1.66-4.33) (3.92-6.17) (1.00-7.75)
4 H-S 1.92 2.42 1.58 4.00 2.00
5 H-S 2.50 5.08 1.50 9.92 2.08
6 H-S 5.17 8.33 1.50 13.00 2.92
7 H-S 2.00 21.00 4.00 25.00 9.00
8 H-S 7.25 9.42 2.70 12.33 1.10
9 H-S 5.00 6.75 1.17 7.91 2.00
10 H-S 15.92 17.17 1.58 18.75 6.75
11 H-S 3.25 4.75 1.33 6.08 5.42
12 H-S 7.50 12.08 1.25 13.33 6.42
  Mean (SD) 5.61(4.4) 9.67 (6.11) 1.85 (0.92) 12.26 (6.49) 4.19 (2.77)
  Median
(Range)
5.0 8.33 1.5 12.33 2.92
  (1.92–15.92) (2.42–21.0) (1.33–4.0) (4.0–25.0) (1.1–9.0)
13 S 5.00 6.00 2.00 8.00 6.00
14 S 6.00 6.33 3.42 9.75 2.75
15 S 7.00 10.00 3.00 13.00 6.00
16 S 12.00 12.25 3.42 15.67 2.75
17 S 15.92 20.08 1.59 21.67 6.33
18 S 10.00 19.00 5.00 24.00 3.67
19 S 14.00 18.00 5.00 23.00 3.67
20 S 20.00 21.00 4.00 25.00 5.00
  Mean (SD) 11.24 (5.25) 14.08 (6.20) 3.43 (1.25) 17.51 (6.76) 4.52 (1.49)
  Median
(Range)
11.00 15.13 3.42 18.67 4.34
  (5.0–20.0) (6.0–21.0) (1.59–5.00) (8.0–25.0) (2.75–6.33)
  1. Data in italic are the mean and median of the 3 different patient groups