Table 3 Univariate and multivariate Cox proportional hazard model evaluating predictors for disease progression

Univariate analysis

 rs4072037 (A/A)

1.405

4.079

(1.068–15.571)

0.040

 Age (continuous)

−0.001

0.999

(0.944–1.057)

0.966

 Gender (male)

1.323

3.755

(0.808–17.444)

0.091

 Smoking history (current smoker)

3.480

32.452

(0.101–10395.609)

0.237

 BMI (continuous)

−0.056

0.945

(0.837–1.068)

0.367

 FVC (continuous)

−0.042

0.959

(0.918–1.001)

0.058

 PaO₂ (continuous)

−0.126

0.882

(0.804–0.967)

0.008

 A-aDO₂ (continuous)

0.086

1.090

(1.015–1.171)

0.017

 DLco (continuous)

−0.054

0.947

(0.906–0.997)

0.017

 GM-CSF autoantibody (continuous)

−0.023

0.975

(0.938–1.014)

0.201

 KL-6 (continuous)

0.001

1.00

(0.99–1.00)

0.014

 LDH (continuous)

0.006

1.006

(1.000–1.011)

0.022

Multivariate analysis^a

 rs4072037 (A/A)

1.715

5.557

(1.412–21.869)

0.014

 Gender (male)

1.789

5.986

(1.255–28.557)

0.025