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Table 3 Univariate and multivariate Cox proportional hazard model evaluating predictors for disease progression

From: MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis

Variables β HR (95 % CI) p value
Univariate analysis     
 rs4072037 (A/A) 1.405 4.079 (1.068–15.571) 0.040
 Age (continuous) −0.001 0.999 (0.944–1.057) 0.966
 Gender (male) 1.323 3.755 (0.808–17.444) 0.091
 Smoking history (current smoker) 3.480 32.452 (0.101–10395.609) 0.237
 BMI (continuous) −0.056 0.945 (0.837–1.068) 0.367
 FVC (continuous) −0.042 0.959 (0.918–1.001) 0.058
 PaO2 (continuous) −0.126 0.882 (0.804–0.967) 0.008
 A-aDO2 (continuous) 0.086 1.090 (1.015–1.171) 0.017
 DLco (continuous) −0.054 0.947 (0.906–0.997) 0.017
 GM-CSF autoantibody (continuous) −0.023 0.975 (0.938–1.014) 0.201
 KL-6 (continuous) 0.001 1.00 (0.99–1.00) 0.014
 LDH (continuous) 0.006 1.006 (1.000–1.011) 0.022
Multivariate analysisa     
 rs4072037 (A/A) 1.715 5.557 (1.412–21.869) 0.014
 Gender (male) 1.789 5.986 (1.255–28.557) 0.025
  1. aHazard ratio calculated by the Cox proportional hazard model backward stepwise considering the following variables in the model: age, gender, smoking history (current smoker), baseline FVC (%),baseline DLCO (%), PaO2, KL-6 and LDH