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Table 2 Clinical and laboratory profiles of POEMS Syndrome Patients with and without calciphylaxis

From: POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification

  Calciphylaxis P-value
  Present (n = 13) Absent (n = 62)  
Gender; men:women 12:1 40:22 0.043*
Age (years); mean (SD) 58 (11) 57 (11) 0.89
Disease duration 3.1 (2.0) 2.9 (3.3) 0.21
ONLS Leg score >5 46 % 18 % 0.042*
Pleural effusion 54 % 40 % 0.28
Ascites 54 % 13 % 0.0028*
Laboratory data    
VEGF (pg/ml) 4100 (3100) 5100 (5500) (n = 57) 1.0
TNF-α (pg/ml) 18 (24) (n = 7) 8.9 (11) (n = 17) 0.22
IL-6 (pg/ml) 12 (4.4) (n = 5) 4.4 (2.1) (n = 13) 0.0013*
Cre (mg/dl) 0.86 (0.45) 0.94 (0.65) 0.83
Ca (mg/dl) 9.0 (0.48) 8.8 (0.42) 0.19
I-P (mg/dl) 4.1 (0.98) (n = 10) 4.0 (1.2) (n = 54) 0.88
Ca × I-P (mg2/dl2) 36 (8.4) (n = 10) 36 (9.9) (n = 54) 0.89
Albumin (g/dl) 3.1 (0.44) 3.7 (0.54) 0.00035*
Plt (103/μl) 260 (130) 310 (160) 0.21
Treatment    
Corticosteroid 62 % 53 % 0.58
Thalidomide 15 % 8 % 0.35
Melphalan 8 % 19 % 0.29
PBSCT 15 % 3 % 0.14
  1. Data are shown as mean (SD). ONLS, Overall Neuropathy Limitation Scale; VEGF, vascular endothelial growth factor; TNF-α: tumor necrosis factor-α; IL-6: Interleukin-6;
  2. Ca, serum concentration of calcium corrected by albumin concentration; I-P, serum concentration of phosphate; Plt, platelet count; PBSCT: peripheral blood stem cell transplantation
  3. *: p<0.05