Table 2 Clinical and laboratory profiles of POEMS Syndrome Patients with and without calciphylaxis

Gender; men:women

12:1

40:22

0.043*

Age (years); mean (SD)

58 (11)

57 (11)

0.89

Disease duration

3.1 (2.0)

2.9 (3.3)

0.21

ONLS Leg score >5

46 %

18 %

0.042*

Pleural effusion

54 %

40 %

0.28

Ascites

54 %

13 %

0.0028*

Laboratory data

VEGF (pg/ml)

4100 (3100)

5100 (5500) (n = 57)

1.0

TNF-α (pg/ml)

18 (24) (n = 7)

8.9 (11) (n = 17)

0.22

IL-6 (pg/ml)

12 (4.4) (n = 5)

4.4 (2.1) (n = 13)

0.0013*

Cre (mg/dl)

0.86 (0.45)

0.94 (0.65)

0.83

Ca (mg/dl)

9.0 (0.48)

8.8 (0.42)

0.19

I-P (mg/dl)

4.1 (0.98) (n = 10)

4.0 (1.2) (n = 54)

0.88

Ca × I-P (mg²/dl²)

36 (8.4) (n = 10)

36 (9.9) (n = 54)

0.89

Albumin (g/dl)

3.1 (0.44)

3.7 (0.54)

0.00035*

Plt (10³/μl)

260 (130)

310 (160)

0.21

Treatment

Corticosteroid

62 %

53 %

0.58

Thalidomide

15 %

8 %

0.35

Melphalan

8 %

19 %

0.29

PBSCT

15 %

3 %

0.14