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Table 5 Multivariate logistic analyses of any and specific current sleep problems by age, gender and mutation group

From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome

  Any sleep problem Night waking Night screaming Night laughing
  (n = 122) (n = 72) (n = 29) (n = 34)
  n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value
  N = 131    N = 112    N = 116    N = 125   
Age group             
 0 to <5 years 53 (40.5) baseline 48 (42.9) baseline 47 (40.5) baseline 53 (42.4) baseline
 5 to < 10 years 42 (32.1) 13.09 (1.57,109.02) 0.02 36(32.1) 9.16 (2.91,28.86) <0.001 38 (32.8) 1.01 (0.34,3.02) 0.98 40 (32.0) 0.96 (0.32,2.92) 0.95
 10 years or older 36 (27.5) 1.48 (0.45,4.84) 0.52 28 (25.0) 1.80 (0.67,4.85) 0.24 31 (26.7) 1.22 (0.41,3.67) 0.72 32 (25.6) 3.38 (1.20,9.53) 0.02
Gender             
 Female 116 (88.6) baseline 98 (87.5) baseline 101 (87.1) baseline 107 (85.6) baseline
 Male 15 (11.5) 2.37 (0.27,20.53) 0.43 14 (12.5) 0.98 (0.27,3.53) 0.98 15 (12.9) 0.63 (0.16,2.53) 0.52 18 (14.4) 1.86 (0.38,4.05) 0.33
Mutation group             
 No functional protein 45 (34.4) baseline 39 (34.8) baseline 40 (34.5) baseline 40 (34.5) baseline
 Missense/in-frame mutation within catalytic domain 40 (30.5) 0.59 (0.14,2.49) 0.48 33 (29.5) 0.74 (0.26,2.12) 0.58 35 (30.2) 1.37 (0.50,3.78) 0.54 35 (30.2) 1.67 (0.58,4.78) 0.34
 Truncation between aa172 and aa781 30 (22.9) 0.32 (0.08,1.33) 0.12 28 (25.0) 0.32 (0.10,0.99) 0.05 28 (24.1) 0.19 (0.04,0.98) 0.05 28 (24.1) 0.87 (0.26,2.89) 0.82
 Truncation after aa781 16 (12.2) 0.41 (0.06,2.78) 0.37 12 (10.7) 0.24 (0.05,1.08) 0.06 13 (11.2) 0.48 (0.09,2.63) 0.40 13 (11.2) 0.22 (0.02,1.98) 0.18
  1. OR odds ratio - the relative odds of having the outcome in the category of interest compared to the odds of having the outcome in the baseline category; CI confidence interval