Fig. 6

Cadherin-based cell-cell junctions in the cardiomyocytes. Area composita is a mixed-type junctional structure composed of both desmosomal and adherens junctional proteins. Both αE-catenin (αE-cat) and αT-catenin (αT-cat) are present in the area composita at the cardiac intercalated disc, but only αT-catenin was shown to interact directly with PKP2. β-cat: β-catenin; PKG: Plakoglobin; PKP2: Plakophilin-2; DPK: Desmoplakin; IF: Intermediate filaments (From Ref 59, modified)