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Table 3 Change in plasma ammonia concentration from baseline to achievement of normalised plasma ammoniaab

From: Carglumic acid enhances rapid ammonia detoxification in classical organic acidurias with a favourable risk-benefit profile: a retrospective observational study

 

Episodes n

Mean change at NH3 ≤ 60 μmol/L

Mean time to achieve NH3 ≤ 60 μmol/L, days

Total

42

-272.8

2.4

Isovaleric aciduria

3

-299.0

2.3

Methylmalonic aciduria

20

-233.1

1.9

Propionic aciduria

19

-310.5

3.0

Neonates

24

-392.6

2.0

Non-neonates

18

-113.2

3.1

With concomitant ammonia scavengers

14

-344.7

2.3

Without concomitant ammonia scavengers

22

-157.2

2.8

With haemofiltration (with or without ammonia scavengers)

6

-529.3

1.5

  1. aNormalised plasma ammonia defined as NH3 ≤ 60 μmol/L
  2. bEfficacy population
  3. NH3, ammonia