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Table 2 Change in plasma ammonia concentration from baseline to study endpoint in efficacy population

From: Carglumic acid enhances rapid ammonia detoxification in classical organic acidurias with a favourable risk-benefit profile: a retrospective observational study

  Episodes n Mean change in NH3 at endpoint (μmol/L) Mean time to the endpoint, days
Total 48 -292.2 4.6
Isovaleric aciduria 4 -614.3 2.8
Methylmalonic aciduria 25 -229.2 5.2
Propionic aciduria 19 -307.3 4.2
Neonates 29 -407.6 4.0
Non-neonates 19 -116.1 5.6
With concomitant ammonia scavengers 15 -366.0 3.9
Without concomitant ammonia scavengers/haemofiltration 27 -200.2 5.0
With haemofiltration (with or without ammonia scavengers) 6 -521.8 4.8
  1. NH3, ammonia