Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

Table 3 Quality assessment of the studies on paediatric MS (References [28–32, 34–37, 60–62]) and on CJD (References [38–41, 43, 44, 63])

Studies on paediatric MS
AAN scale	Oxford quality scale for RCTs	References
Class II	2 points	[28]
Class III	n/a	[29, 30, 37, 60, 62]
Class IV	n/a	[31, 32, 34–36, 61]
Studies on CJD
AAN scale	Oxford quality scale for RCTs	References
Class I	5 points	[39, 41]
Class I	4 points	[38]
Class III	n/a	[40, 43, 44, 63]

ISSN: 1750-1172