From: Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions
RCT
Clinical endpoints
Prospective analysis
Sample size calculation
Adjustments for multiple testing
Confounding addressed
Industry sponsored
Paediatric MS (n = 12)
1
12
6
2
3
CJD (n = 7)
7
5
4
0