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Table 1 AGREE II instrument-domains and items

From: Review and evaluation of the methodological quality of the existing guidelines and recommendations for inherited neurometabolic disorders

Domain Item
Number Content
1. Scope and purpose 1 The overall objective(s) of the guideline is (are) specifically described
2 The clinical question(s) covered by the guideline is (are) specifically described
3 The population to whom the guideline is mean to apply is specifically described
2. Stakeholder involvement 4 The guideline development group includes individuals from all relevant professional groups
5 The views and preferences of the target population have been sought
6 The target users of the guideline are clearly defined
3. Rigour of development 7 Systematic methods were used to search for evidence
8 The criteria for selecting the evidence are clearly described
9 The strengths and limitations of the body of evidence are clearly described
10 The methods for formulating the recommendations are clearly described
11 The health benefits, side effects, and risks have been considered in formulating the recommendations
12 There is an explicit link between the recommendations and the supporting evidence
13 The guideline has been externally reviewed by experts prior to its publication
14 A procedure for updating the guideline is provided
4. Clarity of presentation 15 The recommendations are specific and unambiguous
16 The different options for management of the condition or health issue are clearly presented
17 Key recommendations are easily identifiable
5. Applicability 18 The guideline describes facilitators and barriers to its application
19 The guideline provides advice and/or tools on how the recommendations can be put into practice
20 The potential resource implications of applying the recommendations have been considered
21 The guideline presents monitoring and/or auditing criteria
6. Editorial independence 22 The views of the funding body have not influenced the content of the guideline
23 Competing interests of guideline development group members have been recorded and addressed
Overall assessment 1 Overall quality of this guideline
2 Would you recommend this guideline for use?