Fig. 7

Results of AGREE II appraisal for individual items. Scores obtained by the identified GLs and RCs on a 7-point scale for item 4 (a), item 7 (b), item 8 (c), item 9 (d), item 10 (e) and item 13 (f). Data are presented as mean ± SD of values obtained by each group of disorders in each item. A: amino acid and organic acid metabolism (n = 8); C: carbohydrate metabolism (n = 9); E: vitamin and non protein cofactor metabolism and transport (n = 2); G: mineral absorption and transport (n = 5); H: energy metabolism (n = 3); I: lysosomal and lysosomal-related organelles (n = 27)