|
Baseline Measurements
| | | | | | |
|---|
| |
Mean (SD)
| |
P value (T-test)
|
aMean % Reference (SD)
| |
P value (t-test)
|
|---|
|
Spirometry
|
Patients n = 5
|
Controls n = 82
| |
Patients n = 5
|
Controls n = 82
| |
|
FEV1 (L)
|
2.2 (1.0)
|
1.85 (0.7)
|
0.354
|
86.0 (8.2)
|
90.8 (22.4)
|
0.636
|
|
FVC (L)
|
2.5 (1.2)
|
2.28 (0.9)
|
0.576
|
89.8 (11.8)
|
100.7 (17.6)
|
0.178
|
|
FEV1/FVC (%)
|
86.8 (3.4)
|
82.0 (9.9)
|
0.282
| | | |
|
PEF (L/sec)
|
6.2 (3.6)
|
4.0 (1.6)
|
0.007
|
104.8 (25.5)
|
95.1(25.8)
|
0.418
|
|
Impulse oscillometry
|
Patients n = 10
|
Controls n = 82
| |
Patients n = 10
|
Controls n = 82
| |
|
R5 (cmH20/L/sec)
|
8.4 (3.3)
|
7.8 (2.3)
|
0.488
|
122.3 (33.3)
|
103.4 (24.7)
|
0.032
|
|
R10 (cmH20/L/sec)
|
6.9 (2.5)
|
6.4 (1.7)
|
0.451
|
112.3 (33.9)
|
95.9 (22.4)
|
0.044
|
|
R20 (cmH20/L/sec)
|
5.7 (1.9)
|
5.4 (1.3)
|
0.592
|
98.0 (27.0)
|
93.8 (22.5)
|
0.592
|
|
R5-R20 (%)Δ
|
30.6 (9.4)
|
29.6 (11.0)
|
0.780
| | | |
|
X5 (cmH20/L/sec)
|
−3.6 (1.8)
|
−3.0 (1.3)
|
0.231
|
182 (78.7)
|
118.7 (50)
|
0.001
|
|
AX (cmH20/L)
|
27.5 (21.6)
|
22.4 (14.6)
|
0.323
| | | |
|
Fres Hz
|
22.2 (6.3)
|
20.5 (4.4)
|
0.280
| | | |
|
X5ref-X5 (cmH20/L/sec)
|
1.3 (1.2)
|
0.35 (1.3)
|
0.041
| | | |
-
aNormal cut-off: Spirometry >80 % Reference; IOS: R5, R10, R20, <140 % Ref, X5ref-X5 < 1.5 cm H20/L/sec, ΔR5-R20 < 35 %
