Skip to main content

Table 3 Baseline results in patients vs. controls

From: Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency

Baseline Measurements       
  Mean (SD)   P value (T-test) aMean % Reference (SD)   P value (t-test)
Spirometry Patients n = 5 Controls n = 82   Patients n = 5 Controls n = 82  
FEV1 (L) 2.2 (1.0) 1.85 (0.7) 0.354 86.0 (8.2) 90.8 (22.4) 0.636
FVC (L) 2.5 (1.2) 2.28 (0.9) 0.576 89.8 (11.8) 100.7 (17.6) 0.178
FEV1/FVC (%) 86.8 (3.4) 82.0 (9.9) 0.282    
PEF (L/sec) 6.2 (3.6) 4.0 (1.6) 0.007 104.8 (25.5) 95.1(25.8) 0.418
Impulse oscillometry Patients n = 10 Controls n = 82   Patients n = 10 Controls n = 82  
R5 (cmH20/L/sec) 8.4 (3.3) 7.8 (2.3) 0.488 122.3 (33.3) 103.4 (24.7) 0.032
R10 (cmH20/L/sec) 6.9 (2.5) 6.4 (1.7) 0.451 112.3 (33.9) 95.9 (22.4) 0.044
R20 (cmH20/L/sec) 5.7 (1.9) 5.4 (1.3) 0.592 98.0 (27.0) 93.8 (22.5) 0.592
R5-R20 (%)Δ 30.6 (9.4) 29.6 (11.0) 0.780    
X5 (cmH20/L/sec) −3.6 (1.8) −3.0 (1.3) 0.231 182 (78.7) 118.7 (50) 0.001
AX (cmH20/L) 27.5 (21.6) 22.4 (14.6) 0.323    
Fres Hz 22.2 (6.3) 20.5 (4.4) 0.280    
X5ref-X5 (cmH20/L/sec) 1.3 (1.2) 0.35 (1.3) 0.041    
  1. aNormal cut-off: Spirometry >80 % Reference; IOS: R5, R10, R20, <140 % Ref, X5ref-X5 < 1.5 cm H20/L/sec, ΔR5-R20 < 35 %