Fig. 5

HPßCD counteracts the myelin loss of Npc1 ^−/− mice. Brain sections of PN75, either sham or HPßCD-treated, Npc1 ^+/+ and Npc1 ^−/− mice were immunostained with anti-myelin basic protein antibody (brown). Representative fields (see Additional file 3: Figure S3) of parasagittal sections of a primary visual cortex b primary somatosensory cortex, and c transversal sections of optic nerve are shown in the figure. The robust myelin reduction of Npc1 ^−/− mice was partially rescued by HPßCD administration. I–VI: cortical layers; fmj: forceps major corpus callosum; CPu: caudate putamen (striatum). Scale bars indicate 50 μm (a, b) and 6 μm (c)