Fig. 2

VEP components of naïve/sham PN75 Npc1 ^+/+ and Npc1 ^−/− mice. a Representative VEPs are shown in panel a (see Fig. 1 for description). Note the different values of N1 peak latency and amplitude (arrows) depending on experimental manipulation and/or genotype. b, c Histograms indicate the mean ± SEM of N1 latency and amplitude values obtained in the experimental groups indicated in the panels. Note that the latency of sham Npc1 ^+/+ mice significantly decreased compared to that of naïve Npc1 ^+/+ mice, whereas sham and naïve Npc1 ^−/− mice had similar latency. The amplitude of sham mice, either Npc1 ^+/+ or Npc1 ^−/− , did not significantly differ from each other, but were significantly reduced compared to that of Npc1 ^+/+ naïve mice. Asterisks indicate statistically significant differences among experimental groups (***, p < 0.001)