Skip to main content
Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Early treatment with laronidase improves clinical outcomes in patients with attenuated MPS I: a retrospective case series analysis of nine sibships

Fig. 3

Spinal radiographs from sibship 2 patients. Panel a and b show radiographs of the older sibling at age 8, after 5 years of ERT. Note the ‘S’ shaped scoliosis with right-sided convexity in the thoracic region and left-sided convexity in the lumbar region as well as gibbus deformity at L1 and L4. There is retrolisthesis of L4 with respect to L5 and possible compromise in the spinal canal at L1 and L4. Small anterior beaking is noted in the lower thoracic and lumbar vertebrae. Panel c and d are spinal radiographs of the younger sibling at age 10, after 10 years of ERT. Note the absence of spinal deformity with only minimal anterior beaking of the lower thoracolumbar vertebrae

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172