Fig. 1

Symptoms present at T1 for Older (OS) and Younger (YS) Siblings. Frequency of signs and symptoms at T1 was determined from a maximum of 14 possible symptoms that included coarse facial features, corneal clouding, hearing loss, sleep apnea, abnormal lung function tests, cardiac abnormalities, hepatomegaly, splenomegaly, hernia, dysostosis multiplex, joint contractures/other skeletal defects, motor developmental delay, language/cognitive delay, and restrictions in ADL