Fig. 1

Dose response and duration of TTR knockdown. Mean (±SEM) percentage of baseline serum concentration–time profile. Q3W: every 3 weeks; Q4W: every 4 weeks; SEM: standard error of the mean; TTR: transthyretin. *Includes first dose data from additional patient prior to protocol amendment. ^†Excludes post-Day 28 data from patient who experienced drug extravasation during second infusion. ^‡One patient discontinued before the second dose of patisiran