Table 1 Characteristics of included studies
Study type | Case report | Cohort prospective | |||||||
|---|---|---|---|---|---|---|---|---|---|
Studies | Franz 2006 | Wienecke 2006 | Birca 2010 | Lam 2010 | Krueger 2010 | Dabora 2011 | Lopez 2011 | Davies 2011 | |
na | 3 | 1 | 1 | 1 | 28 | 36 | 17 | 10 | |
Sex | M | 1 | 1 | Â | 1 | 17 | 10 | 8 | NS |
F | 2 | Â | 1 | Â | 11 | 26 | 9 | ||
Age range (years) | 14.5 – 21 | 19 | 8 | 9 | 3 – 34 | 19 – 60 | >10 | NS | |
Genotype | TSC1 | Â | Â | Â | Â | 4 | Â | Â | Â |
TSC2 | 3 | 1 | 1 | 1 | 10 | 14 | Â | Â | |
Unknown | Â | Â | Â | Â | 14 | 22 | 17 | 10 | |
Rapamycin | Dose (mg/day) | 2 – 7 | 0.5 | 1 | 5 – 7 | 3b | 2 – 6 | 1 | 0.5c |
Trough (ng/ml) | 7.7 – 10.9 | 4 – 5 | 3.3 – 4.5 | 10 – 15 | 5 – 15 | 3 – 15 | 4 – 8d | 3 – 6 | |